Buy FOXO4-DRI Peptide Norway
Buy FOXO4-DRI peptide, a therapeutic agent that targets cellular senescence. It belongs to the Forkhead box O (FOXO) family of transcription factors. Potential benefits include reducing oxidative stress, improving tissue regeneration, and mitigating aging-related diseases.
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FOXO4-DRI Nasal Spray
£203.69 – £402.38 This product has multiple variants. The options may be chosen on the product page -
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FOXO4-DRI 10mg Pre Mixed
£202.53 – £546.83 This product has multiple variants. The options may be chosen on the product page -
FOXO4-DRI
£197.40 – £206.38 This product has multiple variants. The options may be chosen on the product page
What Is FOXO4-DRI?
FOXO4-DRI is a synthetic peptide designed to break the interaction between FOXO4 and p53 proteins in senescent cells. It has gained attention in ageing and cellular research for its potential to clear damaged or senescent cells without harming healthy ones. By targeting the FOXO4-p53 pathway, FOXO4-DRI restores the ability of these cells to undergo apoptosis, the natural process of cell death, which senescent cells often resist.
Senescent cells build up over time due to stressors like oxidative stress and DNA damage. This buildup contributes to ageing and age-related conditions such as tissue dysfunction and metabolic disorders. FOXO4-DRI blocks FOXO4’s anti-apoptotic effect, allowing p53 to guide these cells to self-destruct through apoptosis. Its selective action minimizes effects on healthy, non-senescent cells, making it a promising therapeutic option.
FOXO4-DRI is currently under study in both lab and animal models to assess its biological activity, solubility in solvents like DMSO, and overall effectiveness. With potential applications in treating age-related diseases and promoting tissue regeneration, it represents an exciting development in longevity research. Proper handling, storage (typically in freezers), and adherence to Good Manufacturing Practices (GMP) are essential to maintaining its purity and bioactivity.
FOXO4-DRI Mechanism Of Action
FOXO4-DRI works by targeting the interaction between the FOXO4 protein and p53, a key tumor suppressor protein that regulates cell life and death. Normally, FOXO4 binds to p53 in senescent cells, stopping it from triggering cell death (apoptosis). This allows senescent cells to survive, contributing to aging and related diseases. FOXO4-DRI disrupts this process by mimicking the part of FOXO4 that interacts with p53, blocking their binding.
When the FOXO4-p53 interaction is blocked, p53 regains its ability to trigger apoptosis in senescent cells, while mostly sparing healthy cells. This targeted approach minimizes side effects by avoiding unnecessary cell death. By clearing senescent cells, FOXO4-DRI may help restore tissue function and slow down the progression of age-related diseases. Its precise mechanism highlights its potential as an innovative therapy in regenerative medicine.
Structure of FOXO4-DRI
Sequence: H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-Gly-Gly-Lys-Arg-Pro-DL-Pro-DL-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-OH
Molecular Formula:
C228H388N86O64
Molecular Weight:
5358 g/mol
PubChem CID: 168431240
What Are The Research Benefits of FOXO4-DRI
Cellular Senescence Prevention: FOXO4-DRI peptide has been shown to target and disrupt the interaction between FOXO4 and p53 in senescent cells, promoting programmed cell death in cells that are no longer functional. This may help in reducing the accumulation of damaged cells associated with age-related decline [1].
Anti-Ageing Properties: By clearing senescent cells, the peptide has the potential to mitigate signs of aging, improve tissue function, and enhance overall physiological resilience [2].
Enhanced Longevity: By targeting the root causes of cellular ageing, the peptide could contribute to increased lifespan and improved quality of life, though further studies are required to substantiate these claims [3].
Improved Tissue Regeneration: The removal of senescent cells can allow for better cellular regeneration, supporting the maintenance and repair of tissues throughout the body [1].
Potential Treatment for Age-Related Diseases: FOXO4-DRI may play a role in combating diseases such as osteoarthritis, atherosclerosis, and other conditions linked to the accumulation of senescent cells [4].
Cardiovascular Health: The FOXO4-DRI peptide shows great potential in combating heart disease by targeting and reducing senescent cells in cardiovascular tissues. This approach could enhance heart function and address key factors that contribute to age-related cardiac conditions [5].
Neurodegenerative Disease: FOXO4-DRI may provide therapeutic benefits in combating neurodegenerative conditions, such as Alzheimer’s and Parkinson’s disease, by reducing the accumulation of senescent cells in neural tissues, which could help preserve cognitive function and slow disease progression [6].
Hypogonadism: FOXO4-DRI shows potential in addressing hypogonadism by targeting and reducing senescent cells in reproductive tissues. This may aid in improving hormonal balance and mitigating symptoms associated with age-related hormonal decline [7].
Hair Loss: FOXO4-DRI presents potential in addressing hair loss by targeting senescent cells within hair follicles. By reducing cellular senescence, it may promote healthier follicle function and support the regeneration of hair growth in age-related or stress-induced hair thinning [1].
Possibly Reduced Chronic Inflammation: Senescent cells often contribute to chronic inflammation through the SASP (Senescence-Associated Secretory Phenotype). Clearing these cells may reduce inflammation, benefiting overall health [1].
Potential for Targeted Therapeutics: Unlike other treatments, FOXO4-DRI specifically targets senescent cells without adversely affecting healthy, non-senescent cells, underscoring its precision in therapeutic applications [1].
Buy FOXO4-DRI Pre Mixed Pen Norway for research online today! 10mg Pre-Mixed Cartridge Kits include a cartridge (premixed with your chosen peptide and Bacteriostatic Water), a pen, carry case, and 3 needle tips. Single cartridges (1, 2, or 3) come with 3 needle tips but no kit. Save 10% when purchasing 3 cartridges.
What are “DRI” Retro Inverso Peptides?
DRI “Retro-Inverso” peptides are synthetic peptides designed to improve stability and bioavailability while keeping their biological activity intact.
They are created by reversing the amino acid sequence of the original peptide and replacing the natural L-amino acids with D-amino acids. This modification produces a peptide that mimics the function of the original but is much more resistant to enzymatic breakdown.
Retro-inverso peptides are especially useful in therapeutic applications because their increased stability extends their half-life in the body, making them more effective for in vivo use. They are also better at penetrating cell membranes, which enhances their ability to target intracellular pathways.
This innovative design allows peptides like FOXO4-DRI to combine functionality with durability, making them promising tools for developing targeted therapies.
Buy FOXO4-DRI Peptide Nasal Spray
Buy FOXO4-DRI nasal spray, available in 15 ml and 30 ml. By bypassing oral or injectable routes, it aims to offer a more direct and less invasive treatment. Though still in early research, it could be a breakthrough in senolytic therapies for ageing and related diseases.
Frequently Asked Questions (FAQs) about FOXO4-DRI
What Are Senescent Cells?
Senescent cells are old or damaged cells that stop dividing but stay active in the body. This natural process, called cellular senescence, helps prevent damaged cells from multiplying and causing cancer. However, over time, the buildup of these cells can contribute to ageing and related diseases.
Senescent cells release harmful substances called the senescence-associated secretory phenotype (SASP), including inflammatory factors, growth factors, and enzymes. SASP can damage tissues by causing inflammation, disrupting structure, and affecting nearby cells. While the immune system typically clears these cells, it becomes less effective with age, allowing them to accumulate and worsen tissue damage.
Studying senescent cells is key to slowing ageing and improving health. Treatments like senolytics, such as FOXO4-DRI, aim to remove these cells, restore tissue function, and promote healthy ageing.
Is FOXO4-DRI safe for humans?
FOXO4-DRI is still under significant research and clinical evaluation. Most studies have been conducted in laboratory and animal models, with limited human clinical trials completed to date. Therefore, its long-term safety and efficacy in humans remain under investigation, and it is not yet approved for therapeutic use.
Is FOXO4-DRI legal?
At present, FOXO4-DRI is not approved for clinical or therapeutic use in humans by major regulatory authorities such as the FDA, EMA, or MHRA. Its legal status is largely restricted to research applications, and it is typically only available for purchase by accredited institutions or laboratories conducting scientific studies.
Consequently, the substance is not legally accessible for personal or non-research use in most jurisdictions.
Where is FOXO4-DRI currently being studied?
FOXO4-DRI is primarily being studied in the field of biogerontology and regenerative medicine. Research institutions and biotechnology companies are exploring its potential applications in combating age-related diseases, managing chronic conditions, and enhancing longevity.
Can FOXO4-DRI cure ageing?
While FOXO4-DRI has shown promise in addressing aspects of cellular ageing, it is not a cure for ageing. It is a targeted therapy aimed at mitigating the effects of senescent cells, which are just one factor in the complex process of ageing. Further study is needed to determine its role within broader anti-ageing strategies.
Buy FOXO4-DRI Peptide Vial Norway from Direct Peptides. Available in 10 mg vial and also in a convenient kit with bacteriostatic water for reconstituting the lyophilized power.
Summary of Research Applications
- Promotes cellular senescence clearance, aiding in anti-aging research.
- Potentially reduces age-related tissue dysfunction and promotes tissue regeneration.
- Investigated for its role in improving organ health and longevity.
- May contribute to therapies targeting age-associated diseases such as arthritis and cardiovascular conditions.
- Explored for its potential in cancer research due to its influence on cell cycle regulation.
FOXO4-DRI Peptide Quality Assured
Buy FOXO4-DRI Norway 99% pure from Direct Peptides designed for research purposes. Manufactured with strict quality controls, these peptides support studies on cellular aging, inflammation reduction, and regenerative medicine, providing reliable and consistent results for scientific innovation.
References For Further Reading
[1] Marjolein P Baar, Renata MC Brandt, Diana A Putavet, Julian DD Klein, et al (2017) Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging – Cell, 2017 Mar 23, Volume 169 (Issue 1), Pages 132–147.e16.
[2] Jianhui Chang, Yingying Wang, Lijian Shao, Remi-Martin Laberge, et al (2016) Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice – Nature Medicine, 2016 Jan, Volume 22 (Issue 1), Pages 78-83.
[3] Albert Tzong-Yang Chen, Chunfang Guo, Omar A Itani, Breane G Budaitis, et al (2015) Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans – Genetics, 2015 Oct, Volume 201 (Issue 2), Pages 613-29.
[4] Yuzhao Huang, Yuchen He, Meagan J Makarcyzk, Hang Lin. et al (2021) Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes – Frontiers in Bioengineering and Biotechnology, 2021 Apr 29, Volume 9, Page 677576.
[5] Anne-Laure Bulteau, Luke I. Szweda, and Bertrand Friguet (2002) Age-Dependent Declines in Proteasome Activity in the Heart – Archives of Biochemistry and Biophysics, Volume 397, Issue 2, 15 January 2002, Pages 298-304.
[6] Wei Hu, Zhi Yang, Wenwen Yang, Mengzhen Han, Baoping Xu, et al (2019) Roles of forkhead box O (FoxO) transcription factors in neurodegenerative diseases: A panoramic view – Progress in Neurobiology, 2019 Oct, Volume 181, Page 101645.
[7] Chi Zhang, Yun Xie, Haicheng Chen, Linyan Lv, et al (2020) FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice – Aging (Albany NY), 2020 Jan 20, Volume 12 (Issue 2), Pages 1272–1284.
Why Choose Direct Peptides Norway?
Buy FOXO4-dri Norway from Direct Peptides, your trusted source for high-quality peptides. We provide a variety of FOXO4-DRI formulations tailored to the needs of researchers, including peptide vials, nasal sprays, and ready-to-use pre-mixed pens. Experience unmatched quality and reliability with our premium products.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Norway Direct Peptides website: https://norway.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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